Disease Management Update
Volume IV, No. 31
November 29, 2007

Dear Healthcare Intelligence Network Client,

You know what they say — you are what you eat. And what you eat can have a great impact on your health. Recent studies show that diets rich in some ingredients can help reduce the risk and stunt the growth of certain types of cancer. Visit HIN's blog to read about some problems that diet can create.

Your colleague in the business of healthcare,
Laura M. Greene
Editor, Disease Management Update

If this is a forwarded copy of Disease Management Update and you like what you see, you can register to receive your own copy of this complimentary service. Sign up at:

Table of Contents

  1. Flavonoid Helps Women Decrease Risk of Ovarian Cancer
  2. Disease Management Q&A: Identifying Undiagnosed Diseases with DM
  3. HealthSounds Podcast: DM & the Medicaid Population
  4. A Low-carb Diet May Stunt Prostate Tumor Growth
  5. Survey of the Month: MRSA Education and Prevention
  6. DM for Chronically Ill and High-cost Patients

1. Flavonoid Helps Women Decrease Risk of Ovarian Cancer

Frequent consumption of foods containing the flavonoid kaempferol, including non-herbal tea and broccoli, was associated with a reduced risk of ovarian cancer, according to new research from Brigham and Women’s Hospital (BWH). Researchers also found a decreased risk in women who consumed large amounts of the flavonoid luteolin, which is found in foods such as carrots, peppers and cabbage. These findings appear in the November 15, 2007 issue of the International Journal of Cancer.

For the study, researchers calculated intake of the flavonoids myricetin, kaempferol, quercetin, luteolin and apigenin among 66,940 women enrolled in the Nurses' Health Study. Although total intake of these five common dietary flavonoids was not clearly beneficial, the researchers found a 40 percent reduction in ovarian cancer risk among the women with the highest kaempferol intake, compared to women with the lowest intake. They also found a 34 percent reduction in the risk of ovarian cancer among women with the highest intake of luteolin, compared to women with the lowest intake.

“This is good news because there are few lifestyle factors known to reduce a woman’s risk of ovarian cancer,” said first author Margaret Gates, ScD, who is a research fellow at BWH. “Although additional research is needed, these findings suggest that consuming a diet rich in flavonoids may be protective.”

To read more about this study and the program, please visit:

2. Disease Management Q&A: Identifying Undiagnosed Diseases with DM

Each week, healthcare professionals respond to a reader's query on an industry issue. This week's experts are Dr. Philip Bonaparte, M.D., chief medical officer with Horizon NJ Health, David Hunsaker, president of public programs with APS Healthcare, and Elizabeth Reardon, M.P.H., managed care director of Vermont Health Access.

Question: Do programs such as the diabetes management do anything to identify undiagnosed diabetes, or are they strictly for those that have already been diagnosed?

Response: (Philip Bonaparte) Our program is for those who have a diagnosis of diabetes. There are those programs that are looking at a prediabetic. Most people with Body Mass Indexes at 40 or above are at high risk of developing Type 2 diabetes. We have a program that looks at obese people, and our focus is on getting them involved and active while trying to prevent them from becoming prediabetics.

(Elizabeth Reardon) In Vermont, people who were on particular antipsychotics drugs — such as olanzapine that can make people gain from 40 to 100 pounds — could be identified as people who probably would be at either immediate or long-term risk. We started doing some outreach strategies on those folks who were receiving those medications.

(David Hunsaker) The metabolic syndrome in particular is one with mental health that can help be a good marker for where we’d have an interest in early identification.

For more details on disease management programs and strategies, please visit:

We want to hear from you! Submit your question for Disease Management Q&A to info@hin.com.

3. HealthSounds Podcast: DM & the Medicaid Population

In this podcast, Dr. Philip M. Bonaparte, chief medical officer of Horizon NJ Health comments on the success of his organization's fourth ER-based caseworker initiative and the information these caseworkers distribute to patients. Bonaparte also comments on the benefits and drawbacks of retail clinics and convenient care clinics and the effect they are having on the healthcare industry at this stage in their existence.

When it comes to making contact with its Medicaid members in Illinois, field work is the name of the game for McKesson Health Solutions. A presence in emergency departments to reduce unnecessary utilization among members and the placement of communication teams in 24 geographical locations around the state is proving successful for McKesson, explains Caryn Jacobi, McKesson's associate V.P. of operations for Illinois. Other efforts include a 24-hour triage line for members and mailings, phone calls and field visits.

Dr. Bonaparte and Jacobi described how their respective organizations target and engage Medicaid enrollees for participation and success in disease management programs.

To listen to this complimentary HIN podcast, please visit:

4. A Low-carb Diet May Stunt Prostate Tumor Growth

A diet low in carbohydrates may help stunt the growth of prostate tumors, according to a new study led by Duke Prostate Center researchers. The study, in mice, suggests that a reduction in insulin production possibly caused by fewer carbohydrates may stall tumor growth.

The researchers compared tumor growth in 75 mice that were eating either a low-carbohydrate diet, a low-fat but high-carbohydrate diet, or a Western diet, high in fat and carbohydrates. The mice that ate a low-carbohydrate diet had the longest survival and smallest tumor size.

"Low-fat mice had shorter survival and larger tumors while mice on the Western diet had the worst survival and biggest tumors," said Stephen Freedland, M.D., a urologist at Duke University Medical Center and lead researcher on the study. "In addition, though both the low-carb and low-fat mice had lower levels of insulin, only the low-carb mice had lower levels of the form of IGF (insulin-like growth factor) capable of stimulating tumor growth."

To learn more about this report's findings, please visit:

5. Survey of the Month: MRSA Education and Prevention

Complete our survey on MRSA education and prevention by November 30, and you'll get a free executive summary of the compiled results.

To participate in this survey and receive its results, please visit:

6. DM for Chronically Ill and High-cost Patients

McKesson Corporation and CMS Health Integrated are providing CoverColorado with the nation’s first integrated care program for high-risk health plan participants. More than 3,000 people with chronic and high-cost health conditions now have access to an around-the-clock, integrated care program that includes both disease management and case management services.

To download this complimentary white paper, please visit:
Please forward this news announcement to your colleagues who might find it useful.
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